Version 3.5.3 was the last major update released by M-Audio.
Getting your M-Audio Radium 49 running on a modern Mac can be a challenge because the keyboard is a "legacy" product that hasn't received official driver updates in years. While it was a staple of early 2000s home studios, its reliance on specific USB drivers makes it difficult to use on recent macOS versions like Ventura, Sonoma, or Sequoia. m-audio radium 49 driver mac
Here is everything you need to know about M-Audio Radium 49 drivers for Mac, from official legacy support to modern workarounds. Official Driver Compatibility (Legacy Systems) Version 3